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Darunavir is an antiretroviral medication used to treat and prevent HIV/ AIDS. It is generally recommended for use with other antiretrovirals. Darunavi is often used with low doses of ritonavir or cobicistat to increase darunavir levels. Darunavi may be used for prevention after a needlestick injury or other potential exposure.Darunavi is taken by mouth once to twice a day.
Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinase inhibitor approved for use in patients with chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). It is being evaluated for use in numerous other cancers, including advanced prostate cancer.
Dazopride is an antiemetic and gastroprokinetic agent of the benzamide class which was never marketed. It acts as a 5-HT3 receptor antagonist and 5-HT4 receptor agonist. In addition to its gastrointestinal effects, dazopride facilitates learning and memory in mice.
Demoxepam is a drug which is a benzodiazepine derivative. It is a metabolite of chlordiazepoxide and has anticonvulsant properties and presumably other characteristic benzodiazepine properties.
Devapamil is a calcium channel blocker.
Diazoxide is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. This switches off voltage-gated calcium ion channels which inhibits the generation of an action potential. It is used as a vasodilator in the treatment of acute hypertension or malignant hypertension. It is also used to decrease hypoglycemia due to the secretion of insulin in disease states such as insulinoma or congenital hyperinsulinism.
Dicumarol is an anticoagulant that functions as a Vitamin K antagonist. It is also used in biochemical experiments as an inhibitor of reductases. It is a natural chemical substance of combined plant and fungal origin. It is a derivative of coumarin, a bitter substance made by plants that does not itself affect coagulation, but which is transformed in mouldy feeds or silages by a number of species of fungi, into active dicumarol. Dicumarol does affect coagulation, and was discovered in mouldy wet sweet-clover hay, as the cause of a naturally-occurring bleeding disease in cattle. It was used along with heparin, for the treatment of deep venous thrombosis.
Diltiazem is a non-dihydropyridine member of the class of drugs known as calcium channel blockers, used in the treatment of hypertension, angina pectoris, and some types of arrhythmia. It is also an effective preventive medication for migraine. It is a class 3 anti-anginal drug, and a class IV antiarrhythmic. It is metabolized by and acts as an inhibitor of the CYP3A4 enzyme.
Dimefline is a respiratory stimulant.
Dithranol is an anthraquinone derivative.It accumulates in mitochondria where it interferes with the supply of energy to the cell, probably by the oxidation of dithranol releasing free radicals, and it impedes DNA replication and so slows the excessive cell division that occurs in psoriatic plaques.It is highly effective in the treatment of psoriasis.
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