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X-Gluc, is a chromogenic substrate used in a variety of applications for the detection of the X-glucuronidase enzyme. Upon reduction, X-Gluc produces a localized colour, making it useful in identifying GUS gene presence in most cell types and for the detection of the GUS gene fusion marker in plants.
ABT-737 is a potent small-molecule inhibitor of antiapoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w with markedly higher affinity than previously reported compounds. ABT-737 induces apoptosis in MM cells, including those resistant to conventional therapy.
AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A.
ATL1102 is an antisense drug that ATL is developing for the treatment of multiple sclerosis, or MS. ATL1102 inhibits CD49d, a subunit of Very Late Antigen-4, or VLA-4. Studies in animal models have demonstrated that inhibiting VLA-4 positively affects a number of inflammatory diseases, including MS. We licensed ATL1102 to ATL in December 2001 and in February 2008, ATL licensed ATL1102 to Teva.
ATL1103 is an antisense drug that targets the growth hormone receptor, or GHr, a receptor that, when inhibited, reduces the level of circulating insulin-like growth factor-1, or IGF-1, produced in the liver.
AZD5438 is a potent inhibitor of cyclin-dependent kinase. AZD5438 showed significant antiproliferative activity in human tumor cell lines causing inhibition of the phosphorylation of cdk substrates pRb, nucleolin, protein phosphatase 1a, and RNA polymerase II COOH-terminal domain and blocking cell cycling at G(2)-M, S, and G(1) phases.
Adjudin is a drug which is under development as a potential non-hormonal male contraceptive drug, which acts by blocking the production of sperm in the testes, but without affecting testosterone production.
Alpidem is an anxiolytic drug from the imidazopyridine family, related to the more well known sleeping medication zolpidem. Unlike zolpidem however, alpidem does not produce sedative effects at normal doses, and is instead used specifically for the treatment of anxiety. It was developed by Synthélabo. It was withdrawn from the French market by 1994 and is not approved for marketing anywhere in the world. It was known to act selectively on the α3 receptor subtype and to a lesser extent at the α1 subtype, of the benzodiazepine receptor. However the chemical structure of alpidem is not related to that of the benzodiazepines, and alpidem is thus sometimes referred to as a nonbenzodiazepine.
Aniline is an organic compound. Aniline was first isolated by destructive distillation of indigo by Otto Unverdorben. Aniline is the prototypical aromatic amine. Its main use is in the manufacture of precursors to polyurethane. Aniline is mainly produced in industry in two steps from benzene. First, benzene is nitrated using a concentrated mixture of nitric acid and sulfuric acid at 50 to 60 °C, which gives nitrobenzene. In the second step, the nitrobenzene is hydrogenated, typically at 200–300 °C in presence of various metal catalysts. Aniline reacts with carboxylic acids or more readily with acyl chlorides such as acetyl chloride to give amides. Aniline and its ring-substituted derivatives react with nitrous acid to form diazonium salts. It reacts with nitrobenzene to produce phenazine in the Wohl-Aue reaction.
Arctiin is a lignan found in many plants of the Asteraceae family. It is the glucoside of arctigenin. Arctiin and arctigenin have shown anticancer effects.
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