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Halazepam

Halazepam is a benzodiazepine derivative. It is no longer marketed in the United States. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a trifluoroethyl derivative of nordazepam. While its structure may be similar to chlordiazepoxide and diazepam, it has both less toxicity and less tendency to cause paradoxical hostility and aggression than either of them. It has active benzodiazepine metabolites.

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Halothane

Halothane is an inhalational general anesthetic. It is the only inhalational anesthetic agent containing a bromine atom; there are several other halogenated anesthesia agents which lack the bromine atom and do contain the fluorine and chlorine atoms present in halothane. It is a core medicine in the World Health Organization's "Essential Drugs List", which is a list of minimum medical needs for a basic health care system. Its use in developed countries, however, has been almost entirely superseded by newer inhalational anaesthetic agents.

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Himbacine

Himbacine is an alkaloid isolated from the bark of Australian magnolias. It has been synthesized using a Diels-Alder reaction as a key step. Himbacine's activity as a muscarinic receptor antagonist, with specificity for the Muscarinic acetylcholine receptor M2, made it a promising starting point in Alzheimer's disease research. The development of a muscarinic antagonist based on himbacine failed but an analog is now in clinical trials as a thrombin receptor antagonist.

Properties
Hydantoin

Hydantoin is a heterocyclic organic compound that can be thought of as a cyclic "double-condensation reaction" product of glycolic acid and urea. When hydantoin reacts with hot, dilute hydrochloric acid, glycine is one of the products. Some N-Halogenated derivatives of hydantoin are used as chlorinating or brominating agents in disinfectant/sanitizer or biocide products. Hydantoin is used as a pharmaceutical intermediate.

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Hydrazine

Hydrazine is an inorganic compound. It is mainly used as a foaming agent in preparing polymer foams, but significant applications also include its uses as a precursor to polymerization catalysts and pharmaceuticals. Additionally, hydrazine is used in various rocket fuels and to prepare the gas precursors used in air bags. It is used within both nuclear and conventional electrical power plant steam cycles to control concentrations of dissolved oxygen in an effort to reduce corrosion. The majority use of hydrazine is as a precursor to blowing agents. It is a useful building block in organic synthesis of pesticides. It is also used as a propellant on board space vehicles, and to both reduce the concentration of dissolved oxygen in and control pH of water used in large industrial boilers.

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Hypericin

Hypericin is a naphtodianthrone, a red-coloured anthraquinone-derivative, which, together with hyperforin, is one of the principal active constituents of Hypericum. It is believed to act as an antibiotic and non-specific kinase inhibitor. It may inhibit the action of the enzyme dopamine β-hydroxylase, leading to increased dopamine levels, although thus possibly decreasing norepinephrine and epinephrine. It derives from polyketides cyclisation.

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ISIS-APOA

ISIS-APOA is an antisense drug we designed to reduce apolipoprotein(a) in the liver to offer a direct approach for reducing Lp(a), an independent risk factor for cardiovascular disease.

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ISIS-GCCR

ISIS-GCCR is an antisense drug that targets the glucocorticoid receptor, or GCCR. Glucocorticoid hormones affect a variety of processes throughout the body, and excessive levels of glucocorticoid hormones can have a detrimental effect on many of the tissues and organs in the body.

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Ibrutinib

Ibrutinib is an experimental drug candidate for the treatment of various types of cancer. It is an orally-administered, selective and covalent inhibitor of the enzyme Bruton tyrosine kinase (Btk).It has given good results in two phase II clinical trials.Ibrutinib has been reported to reduce CLL cell chemotaxis towards the chemokines CXCL12 and CXCL13, and inhibit cellular adhesion following stimulation at the B cell receptor.

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Ibuprofen

Ibuprofen is a nonsteroidal anti-inflammatory drug used for relief of symptoms of arthritis, fever, as an analgesic for pain, especially where there is an inflammatory component, and dysmenorrhea. It is known to have an antiplatelet effect, though it is relatively mild and short-lived when compared with aspirin or other better-known antiplatelet drugs.Ibuprofen also acts as a vasodilator, having been shown to dilate coronary arteries and some other blood vessels.

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