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Pagoclone is an anxiolytic drug from the cyclopyrrolone family, related to better-known drugs such as the sleeping medication zopiclone. It is one of a relatively recently developed class of medicines known as the nonbenzodiazepines, which have similar effects to the older benzodiazepine group, but with quite different chemical structures. It was originally developed as an anti-anxiety drug, but never commercialised. It is a partial agonist acting at GABAA receptors in the brain. In contrast to zopiclone, pagoclone produces anxiolytic effects with little or no sedative or amnestic actions at low doses. This is because pagoclone is a subtype-selective drug which binds primarily to the α2 and α3 subtypes of the GABAA receptor which are responsible for the anti-anxiety effects of these kind of drugs, but has relatively little efficacy at the α1 subtype which produces the sedative and memory loss effects.


Pargyline is an irreversible monoamine oxidase B inhibitor. It has antihypertensive effects. It functions by inhibiting the metabolism of catecholamines and tyramine within presynaptic nerve terminals. Patients taking pargyline must avoid concurrent consumption of tyramine-containing foods such as blue cheese and beer, as this can lead to a hypertensive crisis.


Pentylone is a stimulant compound developed in the 1960s, which has been reported as a novel designer drug.


Phaclofen is a selective antagonist for the GABAB receptor.


Phenytoin is an anticonvulsant drug which can be useful in the treatment of epilepsy.It acts to dampen the unwanted, runaway brain activity seen in seizure by reducing electrical conductance among brain cells. It lacks the sedation effects associated with phenobarbital.Phenytoin acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. By promoting sodium efflux from neurons, phenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient. This includes the reduction of post-tetanic potentiation at synapses.

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Picenadol is a 4-phenylpiperidine derivative that is an opioid analgesic drug. It is an effective analgesic with similar efficacy to pethidine . It has been investigated for some applications such as obstetrics and dentistry, but never commercialised.


Pinazepam is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.


Piracetam is a nootropic drug. It is a cyclic derivative of GABA. It is one of the group of racetams. Piracetam acts on the central nervous system. It is thought to protect the part of the brain called the cerebral cortex against a lack of oxygen. Piracetam is used alongside other medicines in the treatment of cortical myoclonus. Piracetam improves the function of the neurotransmitter acetylcholine via muscarinic cholinergic (ACh) receptors which are implicated in memory processes. It appears to reverse the effects of aging in the brains of mice, reduce levels of lipofuscin in the rat brain, and effective in treating cognitive impairment in alcoholism, effective for improving cognition in Alzheimer's disease and senile dementia patients. Piracetam is useful as a long-term treatment for clotting, coagulation, and vasospastic disorders such as Raynaud's phenomenon and deep-vein thrombosis. It is an extremely safe anti-thrombotic agent that operates through the novel mechanism of inhibiting platelet aggregation and enhancing blood-cell deformability.

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Piribedil is an antiparkinsonian agent and piperazine derivative which acts as a D2 and D3 receptor agonist. It also has α2-adrenergic antagonist properties. The drug has been shown to enhance working memory capacities in normal aging adults. It showed a positive effect in restless legs syndrome.

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