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SKF 82958

SKF 82958 is a synthetic compound of the benzazepine class that acts as a D1 and D5 receptor full agonist. SKF 82958 and similar D1-like-selective full agonists like SKF 81297 and 6-Br-APB produce characteristic anorectic effects, hyperactivity and self-administration in animals, with a similar but not identical profile to that of dopaminergic stimulants such as amphetamine.

SR 142948

SR-142948 is a drug used in scientific research which is a non-peptide antagonist selective for the neurotensin receptors, although not selective between subtypes. It has been used to study the role of neurotensin in the regulation of dopamine receptor activity and glutamate signalling in the brain, and in animal studies SR-142948 blocked the effects of stimulant drugs, including MDMA.


SR-144528 is a drug which acts as a potent and highly selective CB2 receptor inverse agonist, with a Ki of 0.6nM at CB2 and 400nM at the related CB1 receptor. It is used in scientific research for investigating the function of the CB2 receptor, as well as for studying the effects of CB1 receptors in isolation, as few CB1 agonists are available which do not also show significant activity as CB2 agonists. It has also been found to be an inhibitor of acyl-coenzymeA:cholesterol acyltransferase, an effect that appears to be independent from its action on CB2 receptors.

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Safrazine is an irreversible and nonselective monoamine oxidase inhibitor of the hydrazine chemical class that was introduced as an antidepressant in the 1960s.


Saripidem is a sedative and anxiolytic drug in the imidazopyridine family, which is related to the better known drugs zolpidem and alpidem. It has a similar pharmacological profile to the benzodiazepine family of drugs including sedative and anxiolytic properties, but its chemical structure is quite different from that of the benzodiazepine drugs, and saripidem is described as a nonbenzodiazepine. The mechanism of action by which saripidem produces its sedative and anxiolytic effects is by modulating the benzodiazepine binding site on GABAA receptors, however unlike many older GABAA agonists, saripidem is highly subtype selective and binds primarily to the ω1 subtype.


Sch-48461 is a cholesterol absorption inhibitor.


Semaxanib is a selective inhibitor of the tyrosine kinase activity of the vascular endothelial growth factor (VEGF) receptor Flk-1/KDR, is currently in Phase III clinical trials for the treatment of advanced malignancies. Semaxanib inhibits the VEGF-dependent mitogenic/proliferative response of human umbilical vein endothelial cells (HUVECs). In tumor xenograft models, SU5416 inhibits the growth of tumors from a variety of origins by inhibiting tumor angiogenesis.

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Semustine is a drug used in chemotherapy. It is structurally similar to Lomustine


Silibinin is the major active constituent of silymarin, the mixture of flavonolignans extracted from milk thistle consisting of silibinin A and B, isosilibinin A and B, silicristin and silidianin. Both in vitro and animal research suggest that silibinin has hepatoprotective properties that protect liver cells against toxins. It has also demonstrated anti-cancer effects against human prostate adenocarcinoma cells, estrogen-dependent and -independent human breast carcinoma cells, human ectocervical carcinoma cells, human colon cancer cells, and both small and nonsmall human lung carcinoma cells.

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Silodosin is a medication for the symptomatic treatment of benign prostatic hyperplasia. It acts as an α1-adrenoceptor antagonist with high uroselectivity (selectivity for the prostate).

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