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Candoxatril

Candoxatril is only found in individuals that have used or taken this drug. It is the orally-active prodrug of candoxatrilat (UK-73967), the active enantiomer of candoxatrilat (UK-69578), a potent neutral endopeptidase (NEP) inhibitor used in the treatment of chronic heart failure.Neutral endopeptidase inhibitors such as Candoxatril have a dual mechanism of action. They inhibit two metalloprotease enzymes, neutral endopeptidase and ACE, resulting in an increased availability of natriuretic peptides that exhibit vasodilatory effects and, possibly, tissue protective effects.

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Canertinib

Canertinib is an experimental drug candidate for the treatment of cancer. It is an irreversible tyrosine-kinase inhibitor with activity against EGFR.

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Cangrelor

Cangrelor is an intravenous, direct-acting and reversible P2Y12 receptor antagonist.It has a rapid onset and offset of action and achieves significantly greater degrees of platelet inhibition compared with clopidogrel.lt is an investigational antiplatelet agent undergoing testing to enable safe bridging of patients undergoing surgery.

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Cannabinol

Cannabinol is a psychoactive substance cannabinoid found in Cannabis sativa and Cannabis indica or afghanica. It is also a metabolite of tetrahydrocannabinol. It acts as a weak agonist of the CB1 and CB2 receptors, with lower affinity in comparison to tetrahydrocannabinol.

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Canrenone

Canrenone is an aldosterone antagonist with additional antiandrogen properties which is used as a diuretic in Europe. It is a major active metabolite of spironolactone, and is believed to be partially responsible for its effects.

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Capecitabine

Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to 5-fluorouracil in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.Capecitabine is a prodrug that is selectively tumour-activated to its cytotoxic moiety, fluorouracil, by thymidine phosphorylase.

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Capravirine

Capravirine was a non-nucleoside reverse transcriptase inhibitor which reached phase II trials before development was discontinued by Pfizer. Both phase IIb trials which were conducted failed to demonstrate that therapy with capravirine provided any significant advantage over existing triple-drug HIV therapies, and pharmacology studies showed that capravirine may interact with other HIV drugs.

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Capric Acid

Capric acid is a saturated fatty acid. The term capric acid arises from the Latin "capric" which pertains to goats due to their olfactory similarities. Capric acid occurs naturally in coconut oil and palm kernel oil, as well as in the milk of various mammals and to a lesser extent in other animal fats. It is used in organic synthesis and industrially in the manufacture of perfumes, lubricants, greases, rubber, dyes, plastics, food additives and pharmaceuticals.

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Capsaicin

Capsaicin is the active component of chili peppers, which are plants belonging to the genus Capsicum. It is an irritant for mammals, including humans, and produces a sensation of burning in any tissue with which it comes into contact. Because of the burning sensation caused by capsaicin when it comes in contact with mucous membranes, it is commonly used in food products to give them added spice. It is currently used in topical ointments, as well as a high-dose dermal patch, to relieve the pain of peripheral neuropathy such as post-herpetic neuralgia caused by shingles. It may help to treat ear infections such as otitis.

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Capsazepine

Capsazepine is a synthetic analogue of capsaicin. It blocks the painful sensation of heat caused by capsaicin which activates the TRPV1 ion channel. It is therefore considered to be a capsaicin antagonist. The TRPV1 channel functions as a pain and temperature sensor in mammalians. Capsazepine blocks only the activation of TRPV1 channels by chemicals but not by other painful stimuli, like heat. In addition to its effects on TRPV1 channels it was also shown to inhibit the cold activated TRPM8 channel, voltage-activated calcium channels and nicotinic acetylcholine receptors. It mainly serves as a tool to study the TRPV1 ion channel.

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