Proton Pump Inhibitors used in relieving symptoms acid reflux ulcers



RN486,cas 1242156-23-5

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Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It belongs to a class of antisecretory compounds.It is a prodrug in the acid environment of the parietal cells it turns into active sulphenamide form.It is used for the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.

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Tenatoprazole is a proton pump inhibitor indicated for the treatment of reflux oesophagitis and peptic ulcer. It is an imidazopyridine derivative and has an imidazopyridine ring in place of the benzimidazole moiety found in other proton pump inhibitors. It is activated slowly and its inhibition is said to be resistant to reversal. Tenatoprazole has an extended plasma half-life which makes it more effective in the treatment of nocturnal acid breakthrough than esomeprazole.Tenatoprazole is a prodrug of the proton pump inhibitor (PPI) class, which is converted to the active sulfenamide or sulfenic acid by acid in the secretory canaliculus of the stimulated parietal cell of the stomach.

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