14-Methoxymetopon msds| properties| cas no| molecular formula | WorldOfChemicals

14-Methoxymetopon Properties

14-Methoxymetopon

Molecule Structure Image

Description

 

14-Methoxymetopon is an opiate analogue that is a derivative of metopon which has been substituted with a methoxy group at the 14-position. It is a highly potent analgesic drug that is around 500x stronger than morphine when administered systemically; however, when given spinally or supraspinally, it exhibits analgesic activity up to a million fold greater than morphine. It binds strongly to the ?-opioid receptor and activates it to a greater extent than most similar opioid drugs. This produces an unusual pharmacological profile, and although 14-methoxymetopon acts as a potent ?-opioid full agonist in regards to some effects such as analgesia, a ceiling effect is seen on other effects such as constipation and respiratory depression.

Chemical Properties

CAS Number 131575-03-6
Density 1.36g/cm3
IUPAC Name 3-Hydroxy-14-methoxy-5,17-dimethyl-7,8-dihydro-4,5α-epoxy-morphinan-6-one
InChI 1S/C19H23NO4/c1-17-14(22)6-7-19(23-3)13-10-11-4-5-12(21)16(24-17)15(11)18(17,19)8-9-20(13)2/h4-5,13,21H,6-10H2,1-3H3/t13-,17+,18+,19-/m1/s1
InChIKey DENICFHULARDRG-WEZQJLTASA-N
Molar Mass 329.39 g/mol
Molecular Formula C19H23NO4
Synonyms 14-Methoxymetopon;Morphinan-6-one,4,5-epoxy-3-hydroxy-14-methoxy-5,17-dimethyl-, (5a)-