Abciximab Properties, Molecular Formula, Applications - WorldOfChemicals

Abciximab Properties

Abciximab

Molecule Structure Image

Description

 

Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation.Abciximab binds to the intact platelet GPIIb/IIIa receptor, which is a member of the integrin family of adhesion receptors and the major platelet surface receptor involved in platelet aggregation. This binding is thought to involve steric hindrance and/or conformational alterations which block access of large molecules to the receptor rather than direct interaction with the RGD (arginine-glycine-aspartic acid) binding site of GPlIb/IIIa.

Chemical Properties

Brand Name ReoPro(Australia);(Belgium);(Denmark);(Norway);
Reopro 10mg(Germany)
ReoPro 10mg/5ml solution(United Kingdom)
Reopro 2 mg/ml(France)
CAS Number 143653-53-6
Melting Point 61°C
Molar Mass 47455.4 g/mol
Molecular Formula C6462H9964N1690O2049S48
Synonyms 7E3 Antibody
Reopro
Abciximab
AntIGPIIBIIIA
C7e3