Alpidem Properties, Molecular Formula, Applications - WorldOfChemicals

Alpidem Properties


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Alpidem is an anxiolytic drug from the imidazopyridine family, related to the more well known sleeping medication zolpidem. Unlike zolpidem however, alpidem does not produce sedative effects at normal doses, and is instead used specifically for the treatment of anxiety. It was developed by Synthélabo. It was withdrawn from the French market by 1994 and is not approved for marketing anywhere in the world. It was known to act selectively on the α3 receptor subtype and to a lesser extent at the α1 subtype, of the benzodiazepine receptor. However the chemical structure of alpidem is not related to that of the benzodiazepines, and alpidem is thus sometimes referred to as a nonbenzodiazepine.

Chemical Properties

Appearance White to off-white solid
CAS Number 82626-01-5
IUPAC Name 2-[3-Chloro-8-(4-chlorophenyl)-1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-9-yl]-N,N-dipropyl-acetamide
InChI 1S/C21H23Cl2N3O/c1-3-11-25(12-4-2)20(27)13-18-21(15-5-7-16(22)8-6-15)24-19-10-9-17(23)14-26(18)19/h5-10,14H,3-4,11-13H2,1-2H3
Melting Point 136-138°C
Molar Mass 404.332 g/mol
Molecular Formula C21H23Cl2N3O
Synonyms Imidazo[1,2-a]pyridine-3-acetamide,6-chloro-2-(4-chlorophenyl)-N,N-dipropyl-;Alpidem;Ananxyl