Amifostine Properties, Molecular Formula, Applications - WorldOfChemicals

Amifostine Properties


Molecule Structure Image



Amifostine is a cytoprotective adjuvant used in cancer chemotherapy and radiotherapy involving DNA-binding chemotherapeutic agents. Amifostine is used therapeutically to reduce the incidence of neutropenia-related fever and infection induced by DNA-binding chemotherapeutic agents including alkylating agents (e.g. cyclophosphamide) and platinum-containing agents (e.g. cisplatin). It is also used to decrease the cumulative nephrotoxicity associated with platinum-containing agents. Amifostine is also indicated to reduce the incidence of xerostomia in patients undergoing radiotherapy for head and neck cancer.

Chemical Properties

Brand Name Ethyol
CAS Number 20537-88-6
ChEBI 2636
IUPAC Name 2-(3-Aminopropylamino)Ethylsulfanyl Phosphonic Acid
InChI 1S/C5H15N2O3PS/c6-2-1-3-7-4-5-12-11(8,9)10/h7H,1-6H2,(H2,8,9,10)
Molar Mass 214.224 g/mol
Molecular Formula C5H15N2O3PS uses cookies to ensure that we give you the best experience on our website. By using this site, you agree to our Privacy Policy and our Terms of Use. X