Amifostine Properties, Molecular Formula, Applications - WorldOfChemicals

Amifostine Properties

Amifostine

Molecule Structure Image

Description

 

Amifostine is a cytoprotective adjuvant used in cancer chemotherapy and radiotherapy involving DNA-binding chemotherapeutic agents. Amifostine is used therapeutically to reduce the incidence of neutropenia-related fever and infection induced by DNA-binding chemotherapeutic agents including alkylating agents (e.g. cyclophosphamide) and platinum-containing agents (e.g. cisplatin). It is also used to decrease the cumulative nephrotoxicity associated with platinum-containing agents. Amifostine is also indicated to reduce the incidence of xerostomia in patients undergoing radiotherapy for head and neck cancer.

Chemical Properties

Brand Name Ethyol
CAS Number 20537-88-6
ChEBI 2636
IUPAC Name 2-(3-Aminopropylamino)Ethylsulfanyl Phosphonic Acid
InChI 1S/C5H15N2O3PS/c6-2-1-3-7-4-5-12-11(8,9)10/h7H,1-6H2,(H2,8,9,10)
InChIKey JKOQGQFVAUAYPM-UHFFFAOYSA-N
Molar Mass 214.224 g/mol
Molecular Formula C5H15N2O3PS
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