Amitriptyline Properties, Molecular Formula, Applications - WorldOfChemicals

Amitriptyline Properties

Amitriptyline

Molecule Structure Image

Description

 

Amitriptyline is a tricyclic antidepressant. It affects chemicals in the brain that may become unbalanced. Amitriptyline is used to treat symptoms of depression. Amitriptyline may also be used for purposes not listed in this medication guide.It is TGA-labelled for migraine prophylaxis, as it is also is in cases of neuropathic pain disorders, fibromyalgia,and nocturnal enuresis.Amitriptyline is a popular off-label treatment for irritable bowel syndrome.Amitriptyline acts primarily as a serotonin-norepinephrine reuptake inhibitor, with strong actions on the serotonin transporter and moderate effects on the norepinephrine transporter.Amitriptyline is readily absorbed from the gastrointestinal tract and is extensively metabolised on first-pass through the liver.It is metabolised mostly via CYP2D6, CYP3A4, CYP2C19-mediated N-demethylation into nortriptyline.

Chemical Properties

Boiling Point 398.2 °C
Brand Name Elavil;Endep;Levate;Amirol;Amit;Amitone;Amitor;Amitrip
CAS Number 50-48-6
Density 1.076 g/cm3
EINECS Number 200-041-6
IUPAC Name 3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethyl-1-propanamine
InChI 1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3
InChIKey KRMDCWKBEZIMAB-UHFFFAOYSA-N
Melting Point 196-197 °C
Molar Mass 277.41 g/mol
Molecular Formula C20H23N
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