Amitriptyline Properties

Description

Amitriptyline is a tricyclic antidepressant. It affects chemicals in the brain that may become unbalanced. Amitriptyline is used to treat symptoms of depression. Amitriptyline may also be used for purposes not listed in this medication guide.It is TGA-labelled for migraine prophylaxis, as it is also is in cases of neuropathic pain disorders, fibromyalgia,and nocturnal enuresis.Amitriptyline is a popular off-label treatment for irritable bowel syndrome.Amitriptyline acts primarily as a serotonin-norepinephrine reuptake inhibitor, with strong actions on the serotonin transporter and moderate effects on the norepinephrine transporter.Amitriptyline is readily absorbed from the gastrointestinal tract and is extensively metabolised on first-pass through the liver.It is metabolised mostly via CYP2D6, CYP3A4, CYP2C19-mediated N-demethylation into nortriptyline.