Anastrozole Properties, Molecular Formula, Applications - WorldOfChemicals
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Anastrozole Properties

Anastrozole

Disclean-Product_Structure
Molecule 3D Structure Image
Disclean-Molecule 3D Structure
Molecule Structure Image

Description

 

Anastrozole is an aromatase-inhibiting drug approved for treatment of breast cancer after surgery, as well as for metastasis in both pre and post-menopausal women. Anastrozole binds reversibly to the aromatase enzyme through competitive inhibition, inhibits the conversion of androgens to estrogens in peripheral tissues (outside the CNS), and a few CNS sites in various regions within the brain. Anastrozole is not readily biodegraded and has a low potential to bioaccumulate. Anastrozole has been tested for reducing estrogens, including estradiol, in men. It can also contribute to increased risk of stroke, heart attack, chronic inflammation, prostate enlargement and prostate cancer. Anastrozole may be used off-label in children with precocious puberty, or children with pubertal gynecomastia.

Chemical Properties

Brand Name Arimidex
CAS Number 120511-73-1
IUPAC Name 2,2'-[5-(1H-1,2,4-Triazol-1-ylmethyl)-1,3-Phenylene]Bis(2-Methylpropanenitrile)
InChI 1S/C17H19N5/c1-16(2,9-18)14-5-13(8-22-12-20-11-21-22)6-15(7-14)17(3,4)10-19/h5-7,11-12H,8H2,1-4H3
InChIKey YBBLVLTVTVSKRW-UHFFFAOYSA-N
Molar Mass 293.37 g/mol
Molecular Formula C17H19N5
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