Atazanavir Properties, Molecular Formula, Applications - WorldOfChemicals

Atazanavir Properties

Atazanavir

Molecule Structure Image

Description

 

Atazanavir is an antiretroviral drug of the protease inhibitor (PI) class. It is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is the first PI approved for once-daily dosing, and also appears to be less likely to cause lipodystrophy and elevated cholesterol as side effects.Atazanavir selectively inhibits the virus-specific processing of viral Gag and Gag-Pol polyproteins in HIV-1 infected cells by binding to the active site of HIV-1 protease, thus preventing the formation of mature virions. Atazanavir is not active against HIV-2.

Chemical Properties

Appearance Crystalline Solid
Brand Name Reyataz;Latazanavir;Zrivada
CAS Number 198904-31-3
ChEBI 37924
Density 1.178 g/cm3
IUPAC Name Dimethyl (3S,8S,9S,12S)-9-benzyl-3,12-di-tert-butyl-8-hydroxy-4,11-dioxo-6-[4-(2-pyridyl)benzyl]-2,5,6,10,13-pentaazatetradecanedioate
InChI 1S/C38H52N6O7/c1-37(2,3)31(41-35(48)50-7)33(46)40-29(22-25-14-10-9-11-15-25)30(45)24-44(43-34(47)32(38(4,5)6)42-36(49)51-8)23-26-17-19-27(20-18-26)28-16-12-13-21-39-28/h9-21,29-32,45H,22-24H2,1-8H3,(H,40,46)(H,41,48)(H,42,49)(H,43,47)/t29-,30-,31+,32+/m0/s1
InChIKey AXRYRYVKAWYZBR-GASGPIRDSA-N
Melting Point 207-209 °C
Molar Mass 704.87 g/mol
Molecular Formula C38H52N6O7
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