Baclofen Properties, Molecular Formula, Applications - WorldOfChemicals

Baclofen Properties

Baclofen

Molecule Structure Image

Description

 

Baclofen is a derivative of gamma-aminobutyric acid. It is primarily used to treat spasticity and is under investigation for the treatment of alcoholism. It is an agonist for the GABAB receptors. Its beneficial effects in spasticity result from actions at spinal and supraspinal sites. It can also be used to treat hiccups, and has been shown to prevent rises in body temperature induced by the drug MDMA in rats. A very beneficial property of baclofen is that tolerance does not seem to occur to any significant degree-baclofen retains its therapeutic anti-spasmodic effects even after many years of continued use.

Chemical Properties

Appearance White to very faintly yellow solid
Brand Name Kemstro;Lioresal;Gablofen
CAS Number 1134-47-0
ChEBI 2972
Density 1.285 g/cm3
EINECS Number 214-486-9
IUPAC Name (RS)-4-Amino-3-(4-chlorophenyl)butanoic acid
InChI 1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
InChIKey KPYSYYIEGFHWSV-UHFFFAOYSA-N
Melting Point 208-210°C
Molar Mass 213.661 g/mol
Molecular Formula C10H12ClNO2
RTECS Number MW5084200
Synonyms Hydrocinnamicacid, b-(aminomethyl)-p-chloro-;dl-Baclofen;4-Amino-3-(4-chlorophenyl)butanoic acid;Baclofen;b-p-Chlorophenyl-GABA