Bardoxolone Methyl Properties, Molecular Formula, Applications - WorldOfChemicals

Bardoxolone Methyl Properties

Bardoxolone Methyl

Molecule Structure Image

Description

 

Bardoxolone Methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation, and is undergoing clinical development for the treatment of advanced chronic kidney disease (CKD) in type 2 diabetes mellitus patients.

Chemical Properties

Boiling Point 600.8°C
CAS Number 218600-53-4
Density 1.15 g/cm3
IUPAC Name Methyl 2-Cyano-3,12-Dioxooleana-1,9(11)-Dien-28-Oate
InChI 1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22-,24-,29-,30+,31+,32-/m0/s1
InChIKey WPTTVJLTNAWYAO-KPOXMGGZSA-N
Molar Mass 505.69 g/mol
Molecular Formula C32H43NO4
Synonyms RTA 402