Bicalutamide Properties, Molecular Formula, Applications - WorldOfChemicals

Bicalutamide Properties

Bicalutamide

Molecule Structure Image

Description

 

Bicalutamide is an oral non-steroidal anti-androgen used in the treatment of prostate cancer and hirsutism. Bicalutamide acts as a pure anti-androgen by binding to the androgen receptor (AR) and preventing the activation of the AR and subsequent upregulation of androgen responsive genes by androgenic hormones. Bicalutamide is indicated for the treatment of stage D2 metastatic prostate cancer in combination with a luteinizing hormone-releasing hormone analogue or as a monotherapy. It has also been used in clinical trials for ovarian cancer. It has also been used in combination with castration. Bicalutamide is currently tested for treatment of andogen receptor positive metastatic breast cancer.

Chemical Properties

Appearance Off-White Crystalline Solid
Boiling Point 650.3 °C
Brand Name Casodex;Cosudex;Calutide;Kalumid
CAS Number 90357-06-5
IUPAC Name N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-3-[(4-Fluorobenzene)Sulfonyl]-2-Hydroxy-2-Methylpropanamide
InChI 1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)
InChIKey LKJPYSCBVHEWIU-UHFFFAOYSA-N
Melting Point 191-193 °C
Molar Mass 430.37g/mol
Molecular Formula C18H14N2O4F4S
Solubility Insoluble
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