Calcidiol Properties, Molecular Formula, Applications - WorldOfChemicals

Calcidiol Properties

Calcidiol

Calcidiol Structure-Molecule Struture
Molecule Structure Image

Description

 

Calcidiol is a prehormone that is produced in the liver by hydroxylation of vitamin D3 by the enzyme cholecalciferol 25-hydroxylase. Calcifediol is then converted in the kidneys (by the enzyme 25(OH)D-1α-hydroxylase) into calcitriol.Calcitriol binds to intracellular receptors that then function as transcription factors to modulate gene expression.It is produced in the liver and is the best indicator of the body's vitamin D stores. It is effective in the treatment of rickets and osteomalacia, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.It is also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis.

Chemical Properties

Boiling Point 529.2 °C
CAS Number 19356-17-3
ChEBI 17933
Density 1.01 g/cm3
EINECS Number 242-990-9
IUPAC Name (6R)-6-[(1R,3aR,4E,7aR)-4-[(2Z)-2-[(5S)-5-Hydroxy-2-Methylidene-Cyclohexylidene]Ethylidene]-7a-Methyl-2,3,3a,5,6,7-Hexahydro-1H-Inden-1-yl]-2-Methyl-Heptan-2-ol
InChI 1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/t20-,23+,24-,25+,27-/m1/s1
InChIKey JWUBBDSIWDLEOM-DLBXBJKMSA-N
Molar Mass 400.64 g/mol
Molecular Formula C27H44O2
Refractive 1.535 n/D
Synonyms Calcifediol;25-Hydroxyvitamin D3;25-Hydroxycholecalciferol