Calcitriol Properties, Molecular Formula, Applications - WorldOfChemicals

Calcitriol Properties


CF Clear-Product_Structure
Molecule 3D Structure Image
CF Clear-Molecule 3D Structure
Molecule Structure Image



Calcitriol is a form of vitamin D.It is a substance that occurs naturally in the body, and is responsible for increasing levels of calcium in the blood. It is also a medication that is used to treat or prevent low calcium levels due to various diseases.Calcitriol increases levels of calcium in the blood in three different ways.Calcitriol also enhances reabsorption of calcium in the kidneys, and in concert with parathyroid hormone (PTH), stimulates the release of calcium from the bones.Calcitriol is also sometimes used to treat rickets,psoriasis,osteomalacia,and familial hypophosphatemia.The mechanism of action of Calcitriol in the treatment of psoriasis is accounted for by their antiproliferative activity for keratinocytes and their stimulation of epidermal cell differentiation. Calcitriol is also sometimes used to increase the amount of calcium in the blood of premature babies.Calcitriol is produced in the cells of the proximal tubule of the nephron in the kidneys by the action of 25-hydroxyvitamin D3 1-alpha-hydroxylase.

Chemical Properties

Appearance White Crystalline Powder
Boiling Point 565 °C
Brand Name Rocaltrol;Calcijex;Decostriol
CAS Number 32222-06-3
Class 6.1
Density 1.06 g/cm3
EINECS Number 250-963-8
IUPAC Name (1R,5Z)-5-[(2E)-2-[(1R,7aR)-1-(6-hydroxy-6-methylheptan-2-yl)-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
InChI 1/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/t18-,22-,23-,24+,25+,27-/m1/s1
Melting Point 119-121°C
Molar Mass 416.64 g/mol
Molecular Formula C27H44O3
PG 1
RTECS Number FZ4645000
Solubility Insoluble
Synonyms Vitamin D3, 1a,25-Dihydroxy-;1alpha,25-Dihydroxyvitamin D3;1a,25-Dihydroxyvitamin;1alpha,25-Dihydroxycholecalciferol;(5z,7e)-(1s,3r)-9,10-Secocholesta-5,7,10(19)-Triene-1,3,25-Triol;1α,25-Dihydroxycholecalciferol;1,25-Dihydroxyvitamin D3