Chlormadinone Acetate msds| properties| cas no| molecular formula | WorldOfChemicals

Chlormadinone Acetate Properties

Chlormadinone Acetate

Molecule Structure Image



Chlormadinone Acetate is a derivative of naturally secreted progesterone that shows high affinity and activity at the progesterone receptor. It has an anti-estrogenic effect and, in contrast to natural progesterone, shows moderate anti-androgenic properties. It acts by blocking androgen receptors in target organs and by reducing the activity of skin 5alpha-reductase. It suppresses gonadotropin secretion and thereby reduces ovarian and adrenal androgen production. It shows high contraceptive efficacy by inhibiting ovulation due to its ability to suppress or disrupt endogenous gonadotropin secretion and, by this, inhibits follicular growth and maturation. In addition, it suppresses endometrial thickness and increases the viscosity of cervical mucus.

Chemical Properties

Appearance Crystalline Solid
Boiling Point 512.5 °C
CAS Number 302-22-7
Density 1.23 g/cm3
EINECS Number 206-118-0
IUPAC Name 6-Chloro-3,20-Dioxopregna-4,6-Dien-17-yl Acetate
InChI 1S/C23H29ClO4/c1-13(25)23(28-14(2)26)10-7-18-16-12-20(24)19-11-15(27)5-8-21(19,3)17(16)6-9-22(18,23)4/h11-12,16-18H,5-10H2,1-4H3/t16-,17+,18+,21-,22+,23+/m1/s1
Melting Point 212 °C
Molar Mass 404.93 g/mol
Molecular Formula C23H29ClO4
Synonyms 17-(Acetyloxy)-6-Chloropregna-4,6-Diene-3,20-Dione; 17α-Acetoxy-6-Chloro-4,6-Pregnadiene-3,20-Dione