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Clofazimine Properties

Clofazimine

Clofazimine Molecular Structure-Molecule Struture
Molecule Structure Image

Description

 

Clofazimine is a fat-soluble riminophenazine dye used in combination with rifampicin and dapsone as multidrug therapy for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients and Mycobacterium avium paratuberculosis infection in Crohn's disease patients. It also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. Drug is given as an alternative to patients who can not tolerate the effects of dapsone for tuberculosis.

Chemical Properties

Boiling Point 566.9 °C
CAS Number 2030-63-9
ChEBI 3749
Chemical Composition 2-Amino-4-Chlorodiphenylamine
Density 1.29g/cm3
EINECS Number 217-980-2
IUPAC Name N,5-Bis(4-chlorophenyl)-3-(propan-2-ylimino)-3,5-dihydrophenazin-2-amine
InChI 1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3
InChIKey WDQPAMHFFCXSNU-UHFFFAOYSA-N
Molar Mass 473.396 g/mol
Molecular Formula C27H22Cl2N4
NFPA 704 H-2,F-1,R-0,C-NA
RTECS Number SG1578000
Refractive 1.666 n/D
Solubility Insoluble
Synonyms 2-Phenazinamine,N,5-Bis(4-Chlorophenyl)-3,5-Dihydro-3-[(1-Methylethyl)Imino]-;Phenazine,3-(P-Chloroanilino)-10-(P-Chlorophenyl)-2,10-Dihydro-2-(Isopropylimino)-;2-(4-Chloroanilino)-3-Isopropylimino-5-(4-Chlorophenyl)-3,5-Dihydrophenazine;2-P-Chloroanilino-5-P-Chlorophenyl-3,5-Dihydro-3-Isopropyliminophenazine