Cobicistat Properties, Molecular Formula, Applications - WorldOfChemicals

Cobicistat Properties

Cobicistat

Molecule Structure Image

Description

 

Cobicistat is a licensed drug for use in the treatment of infection with the human immunodeficiency virus (HIV).cobicistat is of interest not for its anti-HIV properties, but rather its ability to inhibit liver enzymes that metabolize other medications used to treat HIV, notably elvitegravir, an HIV integrase inhibitor currently under investigation itself. Cobicistat is a component of the four-drug, fixed-dose combination HIV treatment elvitegravir/cobicistat/emtricitabine/tenofovir.Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide fumarate.

Chemical Properties

CAS Number 1004316-88-4
Chemical Composition thiazol-5-ylmethyl (2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanamido)-1,6-diphenylhexan-2-ylcarbamate
Molar Mass 776.02 g/mol
Molecular Formula C40H53N7O5S2
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