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Cytochalasin E Properties

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Cytochalasin E

Molecule Structure Image

Description

Cytochalasin E, a member of the cytochalasin group, is an inhibitor of actin polymerization in blood platelets. It inhibits angiogenesis and tumor growth. Unlike cytochalasin A and cytochalasin B, it does not inhibit glucose transport. Because of its antiangiogenic effect, cytochalasin E is a potential drug for age-related macular degeneration, a kind of blindness caused by an abnormal proliferation of blood vessels in the eye.

Chemical Properties

Appearance	White Powder
Boiling Point	705.1 °C
CAS Number	36011-19-5
Density	1.3 g/cm³
EINECS Number	252-835-7
IUPAC Name	(1Z)-14-Benzyl-6-hydroxy-4,6,15,15a-tetramethyl-3,13,14,14a,15,15a,16a,16b-octahydro[1,3]dioxacyclotridecino[4,5-d]oxireno[f]isoindole-5,10,12(4H,6H)-trione
InChI	1S/C28H33NO7/c1-16-9-8-12-19-23-27(4,35-23)17(2)21-20(15-18-10-6-5-7-11-18)29-24(31)28(19,21)36-25(32)34-14-13-26(3,33)22(16)30/h5-8,10-14,16-17,19-21,23,33H,9,15H2,1-4H3,(H,29,31)/b12-8-,14-13+
InChIKey	LAJXCUNOQSHRJO-WZYRFFTFSA-N
Melting Point	206 °C
Molar Mass	495.56 g/mol
Molecular Formula	C₂₈H₃₃NO₇
RTECS Number	HA5360000
Synonyms	[1,3]Dioxacyclotridecino[4,5-d]oxireno[f]isoindole-5,10,12(4H,6H)-trione,3,13,14,14a,15,15a,16a,16b-octahydro-6-hydroxy-4,6,15,15a-tetramethyl-14-(phenylmethyl)-,(1E,4S,6R,7E,11aS,14S,14aS,15S,15aR,16aS,16bS)-;21,23-Dioxa[13]cytochalasa-13,19-diene-1,17,22-trione,6,7-epoxy-18-hydroxy-16,18-dimethyl-10-phenyl-, (7S,13E,16S,18R,19E)-;NSC 175151;[1,3]Dioxacyclotridecino[4,5-d]oxireno[f]isoindole-5,10,12(4H,6H)-trione,3,13,14,14a,15,15a,16a,16b-octahydro-6-hydroxy-4,6,15,15a-tetramethyl-14-(phenylmethyl)-,[4S-(1E,4R,6S,7E,11aR,14R,14aR,15R,15aS,16aR,16bR*)]-;Cytochalasin E

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