Docetaxel Properties, Molecular Formula, Applications - WorldOfChemicals

Docetaxel Properties

Docetaxel

Docetaxel Molecular Structure-Molecule Struture
Molecule Structure Image

Description

 

Docetaxel is a clinically well-established anti-mitotic chemotherapy medication. It is a semi-synthetic, second-generation taxane, with anti-neoplastic application for the treatment of breast, ovarian, and non-small cell lung cancer. Docetaxel is a taxoid antineoplastic agent. It promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization. Docetaxel interferes with the normal function of microtubule growth, which results in cell- cycle arrest at the G2/M phase and cell death. Docetaxel does not block disassembly of interphase microtubules and so does not prevent entry into the mitotic cycle, but does block mitosis by inhibiting mitotic spindle assembly. Docetaxel is mainly metabolized in the liver by the cytochrome P450 CYP3A4 and CYP3A5 subfamilies of isoenzymes.

Chemical Properties

Appearance Off-White Crystals
Brand Name Taxotere
CAS Number 114977-28-5
ChEBI 4672
Density 1.37 g/cm3
IUPAC Name 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
InChI 1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1
InChIKey ZDZOTLJHXYCWBA-VCVYQWHSSA-N
Melting Point 232°C
Molar Mass 807.88 g/mol
Molecular Formula C43H53NO14
Synonyms Docetaxel Anhydrous
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