EX-527 Properties, Molecular Formula, Applications - WorldOfChemicals

EX-527 Properties


Molecule Structure Image



EX-527 is a cell-permeable, selective inhibitor of SIRT1. It inhibits other SIRTs only at much higher concentrations and has no effect on other HDACs. EX-527 has been used to investigate the relationship between SIRT1-mediated deacetylation of p53, p53 activity, and cell survival following DNA damage

Chemical Properties

CAS Number 49843-98-3
Molar Mass 248.7 g/mol
Molecular Formula C13H13ClN2O
Synonyms 6-?Chloro-?2,?3,?4,?9-?tetrahydro-?1H-?carbazole-?1-?carboxamide