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Fasudil Properties

Fasudil

Molecule Structure Image

Description

 

Fasudil is a potent Rho-kinase inhibitor and vasodilator. Since it was discovered, it has been used for the treatment of cerebral vasospasm, which is often due to subarachnoid hemorrhage, as well as to improve the cognitive decline seen in stroke victims. It has been found to be effective for the treatment of pulmonary hypertension. It was demonstrated in February 2009 that Fasudil could also be used to enhance memory and improve the prognosis of Alzheimers patients.

Chemical Properties

Appearance White crystalline solid
CAS Number 103745-39-7
Density 1.289g/cm3
IUPAC Name 5-(1,4-Diazepane-1-Sulfonyl)Isoquinoline
Molar Mass 291.36 g/mol
Molecular Formula C14H17N3O2S
RTECS Number HM4031166
Solubility >200 mg/ml
Synonyms 1H-1,4-Diazepine,Hexahydro-1-(5-Isoquinolinylsulfonyl)- (9CI);1-(5-Isoquinolinesulphonyl)Homopiperazine;AT 877;Hexahydro-1-(5-Isoquinolinylsulfonyl)-1H-1,4-Diazepine;HA 1077