Gemcitabine Properties, Molecular Formula, Applications - WorldOfChemicals

Gemcitabine Properties

Gemcitabine

Molecule 3D Structure Image
Molecule Structure Image

Description

 

Gemcitabine is a nucleoside analog used as chemotherapy.It is used in non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer. It is being investigated for use in oesophageal cancer, and is used experimentally in lymphomas and various other tumor types.It inhibits thymidylate synthetase, leading to inhibition of DNA synthesis and cell death. Gemcitabine is a prodrug so activity occurs as a result of intracellular conversion to two active metabolites, gemcitabine diphosphate and gemcitabine triphosphate by deoxycitidine kinase. Gemcitabine diphosphate also inhibits ribonucleotide reductase, the enzyme responsible for catalyzing synthesis of deoxynucleoside triphosphates required for DNA synthesis.Gemcitabine triphosphate (diflurorodeoxycytidine triphosphate) competes with endogenous deoxynucleoside triphosphates for incorporation into DNA.

Chemical Properties

Boiling Point 482.7°C
Brand Name DDFC;DFDC;GEO;Gemcin;Gemtro;Gemzar(Australia);(Belgium);(Denmark);(Japan);(New Zealand);Norway);(Sweden)
CAS Number 95058-81-4, 103882-84-4
ChEBI 175901
Density 1.84 g/cm3
InChI 1S/C9H11F2N3O4/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17)/t4-,6-,7-/m1/s1
InChIKey SDUQYLNIPVEERB-QPPQHZFASA-N
Melting Point 168.64°C
Molar Mass 263.198 g/mol
Molecular Formula C9H11F2N3O4
Solubility Soluble