Indapamide Properties, Molecular Formula, Applications - WorldOfChemicals

Indapamide Properties

Indapamide

Molecule Structure Image

Description

 

Indapamide is a benzamide-sulfonamide-indole. It is called a thiazide-like diuretic but structure.Indapamide blocks the slow component of delayed rectifier potassium current (IKs) without altering the rapid component (IKr) or the inward rectifier current. Specifically it blocks or antagonizes the action the proteins KCNQ1 and KCNE1. Indapamide is also thought to stimulate the synthesis of the vasodilatory hypotensive prostaglandin PGE2.Side effects include electrolyte imbalance (potassium or salt depletion due to too much fluid loss), nausea, stomach disorders, vomiting, weakness.

Chemical Properties

Appearance Crystalline Solid
Brand Name Apo-Indapamide(Canada Ontario);(Canada Quebec);Arifon(Poland);Bajaten;Cormil;Damide;Fludex;Gen-Indapamide;Idapamide;Indaflex;Indamol;Ipamix;Lozide(Canada Ontario);(Canada Quebec);Lozol;Natrilix;Natrix;Noranat;Novo-Indapamide(Canada Ontario);(Canada Quebec);Nu-Indapamide(Canada Ontario);(Canada Quebec);Pressurai;Tandix;Tertensif;Veroxil(Italy)
CAS Number 26807-65-8
Density 1.51 g/cm3
Melting Point 160-162°C
Molar Mass 365.83 g/mol
Molecular Formula C16H16ClN3O3S
RTECS Number CV2451200
Synonyms 1-(4-Chloro-3-Sulfamoylbenzamido)-2-Methylindoline;N-(4-Chloro-3-Sulfamoylbenzamido)-2-Methylindoline