Ketoconazole Properties, Molecular Formula, Applications - WorldOfChemicals

Ketoconazole Properties

Ketoconazole

Molecule 3D Structure Image
Molecule Structure Image

Description

 

Ketoconazole is a synthetic antifungal drug used to prevent and treat skin and fungal infections, especially in immunocompromised patients such as those with AIDS or those on chemotherapy. It is sold commercially as an anti-dandruff shampoo, topical cream, and oral tablet. It is very lipophilic, which leads to accumulation in fatty tissues.

Chemical Properties

Appearance White powder
Brand Name Nizoral;Sebizole
CAS Number 65277-42-1
Density 1.38 g/cm3
EINECS Number 265-667-4
IUPAC Name 1-[4-(4-{[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one
InChI 1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1
InChIKey XMAYWYJOQHXEEK-OZXSUGGESA-N
Melting Point 146°C
Molar Mass 531.431 g/mol
Molecular Formula C26H28Cl2N4O4
NFPA 704 H-2,F-1,R-0,C-NA
RTECS Number TK7912300
Synonyms 1-[4-[4-[[(2S,4R)-2-(2,4-Dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone;Ketoconazole