Lamivudine Properties, Molecular Formula, Applications - WorldOfChemicals

Lamivudine Properties

Lamivudine

Lamivudine Molecular Structure-Molecule Struture
Molecule Structure Image

Description

 

Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor (nRTI). It has been used for treatment of chronic hepatitis B at a lower dose than for treatment of HIV. It improves the seroconversion of e-antigen positive hepatitis B and also improves histology staging of the liver. Long term use of lamivudine unfortunately leads to emergence of a resistant hepatitis B virus (YMDD) mutant. Despite this, lamivudine is still used widely as it is well tolerated.

Chemical Properties

Appearance White Crystalline Powder
Brand Name Zeffix;Heptovir;Epivir;Epivir-HBV
CAS Number 134678-17-4
IUPAC Name 4-Amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
InChI 1S/C8H11N3O3S/c9-5-1-2-11(8(13)10-5)6-4-15-7(3-12)14-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7+/m0/s1
InChIKey JTEGQNOMFQHVDC-NKWVEPMBSA-N
Melting Point 177 °C
Molar Mass 229.26 g/mol
Molecular Formula C8H11N3O3S
RTECS Number UW7361333
Synonyms 4-Amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone;Lamivudine;2(1H)-Pyrimidinone,4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-, (2R-cis)-;(-)-2'-Deoxy-3'-thiacytidine;(-)-BCH 189;3TC;BCH189, (-)-;Epivir;Epivir HBV;GR 109714X;Hepitec;Heptodin;Heptovir;L-SddC;Lamivir;Virolam;Zeffix;Zefix;b-L-2',3'-Dideoxy-3'-thiacytidine
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