Letrozole Properties, Molecular Formula, Applications - WorldOfChemicals

Letrozole Properties

Letrozole

Molecule Structure Image

Description

 

Letrozole is an oral non-steroidal aromatase inhibitor for the treatment of hormonally-responsive breast cancer after surgery.It prevents the aromatase from producing estrogens by competitive, reversible binding to the heme of its cytochrome P450 unit.Letrozole is used to treat adolescents and children with short stature.It inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues. It is metabolized slowly to an inactive metabolite whose glucuronide conjugate is excreted renally, representing the major clearance pathway.

Chemical Properties

Appearance White to Off-Whitecrystalline Powder
Boiling Point 374.4 °C
Brand Name Femara
CAS Number 112809-51-5
Density 1.21 g/cm3
IUPAC Name 4,4'-(1H-1,2,4-Triazol-1-Ylmethanediyl)Dibenzonitrile
InChI 1/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H
InChIKey HPJKCIUCZWXJDR-UHFFFAOYAB
Melting Point 100-102 °C
Molar Mass 285.30 g/mol
Molecular Formula C17H11N5