Loratadine Properties, Molecular Formula, Applications - WorldOfChemicals

Loratadine Properties

Loratadine

Molecule Structure Image

Description

 

Loratadine is a second-generation antihistamine drug used to treat allergies. Structurally, it is closely related to tricyclic antidepressants such as imipramine, and distantly related to the atypical antipsychotic quetiapine. It is available as a generic drug and is marketed for its non-sedating properties. In combination with pseudoephedrine it is useful for colds as well as allergies, but adds potential side-effects of insomnia, nervousness, and anxiety.

Chemical Properties

Appearance White crystalline solid
Brand Name Claritin
CAS Number 79794-75-5
Density 1.261 g/cm3
IUPAC Name Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate
InChI 1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
InChIKey JCCNYMKQOSZNPW-UHFFFAOYSA-N
Melting Point 134-136°C
Molar Mass 382.88 g/mol
Molecular Formula C22H23ClN2O2
Synonyms Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylate;1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, ethyl ester;Loratadine
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