Lorazepam Properties, Molecular Formula, Applications - WorldOfChemicals

Lorazepam Properties

Lorazepam

Molecule 3D Structure Image
Molecule Structure Image

Description

 

Lorazepam is a high-potency short-to-intermediate-acting 3-hydroxy benzodiazepine drug.Lorazepam is used for the short-term treatment of anxiety, insomnia, acute seizures including status epilepticus and sedation of hospitalised patients, as well as sedation of aggressive patients.It is considered to be a short-acting drug which, similar to other benzodiazepines, exerts its therapeutic as well as adverse effects via its interaction at benzodiazepine binding sites, which are located on GABAA receptors in the central nervous system.Lorazepam is sometimes used for individuals receiving mechanical ventilation.It is sometimes used as an alternative to haloperidol when there is the need for rapid sedation of violent or agitated individuals,used in chemotherapy as an adjunct to antiemetics for treating anticipatory nausea and vomiting,as adjunct therapy for cyclic vomiting syndrome.

Chemical Properties

Appearance White crystalline solid
Brand Name Ativan;Temesta
CAS Number 846-49-1
Density 1.52 g/cm3
EINECS Number 212-687-6
IUPAC Name (RS)-9-Chloro-6-(2-chlorophenyl)-4-hydroxy-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-3-one
InChI 1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)
InChIKey DIWRORZWFLOCLC-UHFFFAOYSA-N
Melting Point 166-168°C
Molar Mass 321.2 g/mol
Molecular Formula C15H10Cl2N2O2
RTECS Number DF0350000
Synonyms 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one;H-1,4-Benzodiazepin-2-one,7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-;(RS)-Lorazepam;o-Chloroxazepam;2H-1,4-Benzodiazepin-2-one,7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-;Lorazin;Lorazon;Lorenin