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Loviride Properties

Loviride

CAVAMAX W6 Pharma-Product_Structure
Molecule Structure Image

Description

 

Loviride was an antiviral drug manufactured by Janssen that is active against HIV. It is an NNRTI that entered phase III clinical trials in the late 1990s but failed to gain marketing approval because of poor potency. It is of clinical significance only in those patients who were enrolled in clinical trials to evaluate loviride, because in those trials loviride was often given alone and with no companion drug, leading to a high probability of developing reverse transcriptase mutations such as K103N which result in cross-class resistance to all NNRTI's.

Chemical Properties

CAS Number 147362-57-0
Density 1.354g/cm3
IUPAC Name 2-[(2-Acetyl-5-methylphenyl)amino]-2-(2,6-dichlorophenyl)acetamide
InChI 1S/C17H16Cl2N2O2/c1-9-6-7-11(10(2)22)14(8-9)21-16(17(20)23)15-12(18)4-3-5-13(15)19/h3-8,16,21H,1-2H3,(H2,20,23)
InChIKey CJPLEFFCVDQQFZ-UHFFFAOYSA-N
Molar Mass 351.227 g/mol
Molecular Formula C17H16Cl2N2O2
Synonyms Benzeneacetamide, a-[(2-acetyl-5-methylphenyl)amino]-2,6-dichloro-;Loviride;R 89439;Loveride