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Metirosine Properties

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Metirosine

Metirosine-Product_Structure
Molecule Structure Image

Description

  

Metirosine is an antihypertensive drug. It inhibits the enzyme tyrosine hydroxylase and, therefore, catecholamine synthesis, which, as a consequence, depletes the levels of the catecholamines dopamine, adrenaline and noradrenaline in the body. It has been used in the treatment of pheochromocytoma. It is contra-indicated for the treatment of essential hypertension. However it is now rarely used in medicine, and its main use is in scientific research, to investigate the effects of catecholamine depletion on behaviour.

Chemical Properties

Appearance White solid
CAS Number 672-87-7
EINECS Number 211-599-5
IUPAC Name (2S)-2-Amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid
InChI 1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)/t10-/m0/s1
InChIKey NHTGHBARYWONDQ-JTQLQIEISA-N
Melting Point 320-340°C
Molar Mass 195.215 g/mol
Molecular Formula C10H13NO3
Synonyms Metirosine;α-Methyltyrosine;Metyrosine;AMPT;L-Tyrosine, a-methyl-;Tyrosine,a-methyl-, L-
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