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Metirosine Properties

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Metirosine

Molecule Structure Image

Description

Metirosine is an antihypertensive drug. It inhibits the enzyme tyrosine hydroxylase and, therefore, catecholamine synthesis, which, as a consequence, depletes the levels of the catecholamines dopamine, adrenaline and noradrenaline in the body. It has been used in the treatment of pheochromocytoma. It is contra-indicated for the treatment of essential hypertension. However it is now rarely used in medicine, and its main use is in scientific research, to investigate the effects of catecholamine depletion on behaviour.

Chemical Properties

Appearance	White solid
CAS Number	672-87-7
EINECS Number	211-599-5
IUPAC Name	(2S)-2-Amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid
InChI	1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)/t10-/m0/s1
InChIKey	NHTGHBARYWONDQ-JTQLQIEISA-N
Melting Point	320-340°C
Molar Mass	195.215 g/mol
Molecular Formula	C₁₀H₁₃NO₃
Synonyms	Metirosine;α-Methyltyrosine;Metyrosine;AMPT;L-Tyrosine, a-methyl-;Tyrosine,a-methyl-, L-