Natamycin Properties, Molecular Formula, Applications - WorldOfChemicals

Natamycin Properties

Natamycin

Molecule Structure Image

Description

 

Natamycin is a naturally occurring antifungal agent produced during fermentation by the bacterium Streptomyces natalensis, commonly found in soil. Natamycin has a very low solubility in water, due to the amphiphilic nature of the molecule. However, natamycin is effective at very low levels. Natamycin is classified as a macrolide polyene antifungal and, as a drug, is used to treat fungal keratitis. It is especially effective against Aspergillus and Fusarium corneal infections.

Chemical Properties

Appearance White to off-white solid
CAS Number 7681-93-8
Density 1.0 g/ml
EINECS Number 231-683-5
IUPAC Name (1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)-22-[(3-Amino-3,6-Dideoxy-D-Mannopyranosyl)oxy]-1,3,26-Trihydroxy-12-Methyl-10-oxo-6,11,28-Trioxatricyclo[22.3.1.05,7]Octacosa-8,14,16,18,20-Pentaene-25-Carboxylic Acid
InChI 1S/C33H47NO13/c1-18-10-8-6-4-3-5-7-9-11-21(45-32-30(39)28(34)29(38)19(2)44-32)15-25-27(31(40)41)22(36)17-33(42,47-25)16-20(35)14-24-23(46-24)12-13-26(37)43-18/h3-9,11-13,18-25,27-30,32,35-36,38-39,42H,10,14-17,34H2,1-2H3,(H,40,41)/b4-3+,7-5+,8-6+,11-9+,13-12+/t18-,19-,20+,21+,22+,23-,24-,25+,27-,28+,29-,30+,32+,33-/m1/s1
InChIKey NCXMLFZGDNKEPB-FFPOYIOWSA-N
Melting Point 2000 °C
Molar Mass 665.725 g/mol
Molecular Formula C33H47NO13
RTECS Number TK3325000
Synonyms Natamycin;Pimafucin;Pimaricin;Delvocid;Delvolan