Obinutuzumab Properties, Molecular Formula, Applications - WorldOfChemicals

Obinutuzumab Properties

Obinutuzumab

Description

 

Obinutuzumab is a humanized anti-CD20 monoclonal antibody.Obinutuzumab is used in combination with chlorambucil as a first-line treatment for chronic lymphocytic leukemia.Its progression-free survival is better than rituximab in the same combinationbut its overall survival rate is not better.It is also used in combination with bendamustine followed by obinutuzumab monotherapy for the treatment of patients with follicular lymphoma as a second line treatment to a regimen containing rituximab.Obinutuzumab binds to CD20 on B cells and causes these cells to be destroyed by engaging the adaptive immune system, directly activating intracellular apoptosis pathways, and activating the complement system.

Chemical Properties

Molar Mass 146.1 kg/mol
Molecular Formula C6512H10060N1712O2020S44