Palbociclib HCl Properties, Molecular Formula, Applications - WorldOfChemicals

Palbociclib HCl Properties

Palbociclib HCl

Molecule Structure Image



Palbociclib HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib HCl selectively inhibits cyclin-dependent kinases (particularly Cdk4/cyclin D1 kinase), which may inhibit retinoblastoma (Rb) protein phosphorylation;inhibition of Rb phosphorylation prevents Rb-positive tumor cells from entering the S phase of the cell cycle (arrest in the G1 phase), resulting in suppression of DNA replication and decreased tumor cell proliferation. It is a highly specific inhibitor of cyclin-dependent kinase 4 (Cdk4) (IC50 = 0.011?mol/L) and Cdk6 (IC50 = 0.016 ?mol/L), having no activity against a panel of 36 additional protein kinases.

Chemical Properties

CAS Number 827022-32-2
Chemical Composition 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride
Molar Mass 447.5 g/mol
Molecular Formula C24H29N7O2.HCl
Synonyms Palbociclib(PD0332991.HCl);PD 0332991 HCl uses cookies to ensure that we give you the best experience on our website. By using this site, you agree to our Privacy Policy and our Terms of Use. X