Pioglitazone Properties, Molecular Formula, Applications - WorldOfChemicals

Pioglitazone Properties


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Pioglitazone is used for the treatment of diabetes mellitus type 2. Pioglitazone selectively stimulates nuclear receptor peroxisone proliferator-activated receptor gamma (PPAR-gamma). It modulates the transcription of the insulin-sensitive genes involved in the control of glucose and lipid metabolism in the lipidic, muscular tissues and in the liver.Pioglitazone acts as an agonist at peroxisome proliferator activated receptors (PPAR) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of PPAR-gamma receptors regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization. In this way, pioglitazone enhances tissue sensitivity to insulin.Possible hazard hypogycemia

Chemical Properties

Appearance Colourless Prisms
Brand Name Actos;Actost;Glustin
CAS Number 111025-46-8
ChEBI 8228
IUPAC Name (RS)-5-(4-[2-(5-Ethylpyridin-2-yl)Ethoxy]Benzyl)Thiazolidine-2,4-Dione
InChI 1S/C19H20N2O3S/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23)
Melting Point 183-184°C
Molar Mass 356.44 g/mol
Molecular Formula C19H20N2O3S
Solubility 4.4103 mg/ml
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