Progesterone Properties

Description

Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species. Progesterone belongs to a class of hormones called progestogens, and is the major naturally occurring human progestogen.Progesterone is commonly manufactured from the yam family, Dioscorea.It is synthesized from pregnenolone.It can be synthesized within the central nervous system and also serves as a precursor to another major neurosteroid, allopregnanolone.Progesterone has a number of physiological effects that are amplified in the presence of estrogen.It aids in immunity, reduces swelling and inflammation, stimulates and regulates the production of the thyroid gland, and keeps blood-clotting levels at normal values. Progesterone also can be said to be an anti-aging hormone. It keeps bones strong, produces collagen, and helps keep nerves functioning at appropriate levels. Progesterone has key effects via non-genomic signalling on human sperm as they migrate through the female tract before fertilization occurs.Progesterone modulates the activity of CatSper (cation channels of sperm) voltage-gated Ca2+ channels.Progesterone converts the endometrium to its secretory stage to prepare the uterus for implantation.Progesterone is used to support pregnancy in Assisted Reproductive Technology cycles such as In-vitro Fertilization,used to control persistent anovulatory bleeding. It is also used to prepare uterine lining in infertility therapy and to support early pregnancy.