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Quinacrine Properties

Quinacrine

Molecule Structure Image

Description

 

Quinacrine is a drug with a number of different medical applications. It is related to mefloquine. Its main effects are as an antiprotozoal, antirheumatic and an intrapleural sclerosing agent. It is also used "off-label" for the treatment of systemic lupus erythematosus, indicated in the treatment of discoid and subcutaneous lupus erythematosus, particularly in patients unable to take chloroquine derivatives. As an intrapleural sclerosing agent, it is used as pneumothorax prophylaxis in patients at high risk of recurrence.

Chemical Properties

Brand Name Atabrine
CAS Number 83-89-6
ChEBI 8711
Density 1.156 g/cm3
EINECS Number 201-508-7
IUPAC Name (RS)-N'-(6-Chloro-2-methoxy-acridin-9-yl)- N, N-diethyl-pentane-1,4-diamine
InChI 1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26)
InChIKey GPKJTRJOBQGKQK-UHFFFAOYSA-N
Melting Point 247-250 °C
Molar Mass 399.957 g/mol
Molecular Formula C23H30ClN3O
Synonyms 1,4-Pentanediamine,N4-(6-chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-;Acridine,6-chloro-9-[[4-(diethylamino)-1-methylbutyl]amino]-2-methoxy-;6-Chloro-9-[[4-(diethylamino)-1-methylbutyl]amino]-2-methoxyacridine;Quinacrine