Ramipril Properties, Molecular Formula, Applications - WorldOfChemicals

Ramipril Properties


Molecule Structure Image



Ramipril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys. Ramiprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). Ramipril may be used in the treatment of hypertension, congestive heart failure, nephropathy, and to reduce the rate of death, myocardial infarction and stroke in individuals at high risk of cardiovascular events.

Chemical Properties

Brand Name Acovil (Sanofi-Aventis (Spain));Altace (Sanofi-Aventis, King);Carasel (Almirall (Spain));Cardace (Sanofi-Aventis (Finland), Aventis (India), Aventis (Indonesia));Delix (Aventis (Germany, Turkey), );Hypren (AstraZeneca (Austria));Hytren;Lostapres (Temis (Argentina));Pramace (Astra (Ireland), AstraZeneca (Sweden));Quark (Polifarma (Italy));Ramace (Sanofi-Aventis (Australia), Teva (Hungary), AstraZeneca (South Africa));Triatec (Sanofi-Aventis (Brazil, Chili, Denmark, France, Greece, Indonesia, Italy,Norway, Portugal, Sweden, Switzerland));Tritace (Sanofi-Aventis (Argentina, Australia, Austria, Belgium, Czech Republic, Hong Kong, Hungary, Ireland, Israel, Malaysia, Mexico, Netherlands, Poland, Singapor, Thailand, United Kingdom), Aventis (New Zealand, Philippines, South Africa));Vesdil (AstraZeneca (Germany), Promed (Germany)); Unipril
CAS Number 87333-19-5
ChEBI 8774
IUPAC Name (2S,3aS,6aS)-1-[(2S)-2-{[(2S)-1-Ethoxy-1-Oxo-4-Phenylbutan-2-yl]Amino}Propanoyl]-Octahydrocyclopenta[b]Pyrrole-2-Carboxylic Acid
InChI 1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m0/s1
Molar Mass 416.511 g/mol
Molecular Formula C23H32N2O5