Retigabine Properties, Molecular Formula, Applications - WorldOfChemicals

Retigabine Properties


Retigabine Structure-Molecule Struture
Molecule Structure Image



Retigabine is an anticonvulsant used as a treatment for partial epilepsies. Retigabine appears to be free of drug interactions with most commonly used anticonvulsants. It may increase metabolism of lamotrigine (Lamictal), whereas phenytoin (Dilantin) and carbamazepine (CBZ, Tegretol) increase the clearance of retigabine. Retigabine acts as a neuronal KCNQ/Kv7 potassium channel opener, a mechanism of action markedly different from than of any current anticonvulsants.

Chemical Properties

Boiling Point 430°C
Brand Name Trobalt;Potiga
CAS Number 150812-12-7
Density 1.307 g/cm3
IUPAC Name Ethyl {2-Amino-4-[(4-Fluorobenzyl)Amino]Phenyl}Carbamate
InChI 1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21)
Molar Mass 303.33 g/mol
Molecular Formula C16H18FN3O2
Synonyms D-23129;Ezogabine;N-(2-Amino-4-(4-Fluorobenzylamino)Phenyl)Carbamic Acid Ethyl Ester