Rifaximin Properties, Molecular Formula, Applications - WorldOfChemicals

Rifaximin Properties

Rifaximin

Rifaximin Structure-Molecule Struture
Molecule Structure Image

Description

 

Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. It is used to treat diarrhea caused by E. coli.Rifaximin is a product of synthesis of rifamycin, an antibiotic with low gastrointestinal absorption and good antibacterial activity. It acts on the beta-subunit of the deoxyribonucleic acid (DNA)-dependent ribonucleic acid (RNA) polymerase enzyme of microorganisms to inhibit RNA synthesis.

Chemical Properties

Appearance Red-Orange Crystalline Powder
Brand Name Fatroximin;Normix;Rifacol;Ritacol;Xifaxan
CAS Number 80621-81-4
Density 1.36 g/cm3
IUPAC Name (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-1,15-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)furo[2'',3'':7',8']na phtho[1',2':4,5]imidazo[1,2-a]pyridin-25-yl acetate
InChI 1S/C43H51N3O11/c1-19-14-16-46-28(18-19)44-32-29-30-37(50)25(7)40-31(29)41(52)43(9,57-40)55-17-15-27(54-10)22(4)39(56-26(8)47)24(6)36(49)23(5)35(48)20(2)12-11-13-21(3)42(53)45-33(34(32)46)38(30)51/h11-18,20,22-24,27,35-36,39,48-51H,1-10H3,(H,45,53)/b12-11+,17-15+,21-13-/t20-,22+,23+,24+,27-,35-,36+,39+,43-/m0/s1
InChIKey NZCRJKRKKOLAOJ-XRCRFVBUSA-N
Melting Point 200-205°C
Molar Mass 785.879 g/mol
Molecular Formula C43H51N3O11
RTECS Number KD1576000