Rosuvastatin Properties, Molecular Formula, Applications - WorldOfChemicals

Rosuvastatin Properties

Rosuvastatin

Molecule 3D Structure Image
Molecule Structure Image

Description

 

Rosuvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reducuase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Rosuvastatin belongs to a class of medications called statins and is used to reduce plasma cholesterol levels and prevent cardiovascular disease. It is used as an adjunct to dietary therapy to treat primary hypercholesterolemia (heterozygous familial and nonfamilial), mixed dyslipidemia and hypertriglyceridemia and it also indicated for homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering therapies or when other such therapies are not available. It is also used to lower total cholesterol, low density lipoprotein-cholesterol (LDL-C), apolipoprotein B (apoB), non-high density lipoprotein-cholesterol (non-HDL-C), and trigleride (TG) plasma concentrations while increasing HDL-C concentrations.

Chemical Properties

Brand Name Astende (Lazar (Argentina));Cirantan (AstraZeneca (Netherlands));Cresadex (Drugtech (Chile));Crestor (AstraZeneca);Provisacor (AstraZeneca (Italy, Netherlands) );Razel (Glenmark (India));Rosedex (Roux-Ocefa (Argentina));Rosimol (Sandoz (Argentina));Rosumed (Labomed (Chile));Rosustatin (Montpellier (Argentina));Rosuvas (Ranbaxy (India));Rosuvast (Bago (Argentina));Rosvel (Laboratorios Chile (Chile));Rovartal (Roemmers (Argentina));Simestat (Simesa (Italy));Sinlip (Gador (Argentina));Visacor (AstraZeneca (Portugal));Vivacor (AstraZeneca (Brazil))
CAS Number 287714-41-4
IUPAC Name (3R,5S,6E)-7-[4-(4-Fluorophenyl)-2-(N-Methylmethanesulfonamido)-6-(Propan-2-yl)Pyrimidin-5-yl]-3,5-Dihydroxyhept-6-Enoic Acid
InChI 1S/C22H28FN3O6S/c1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32/h5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30)/b10-9+/t16-,17-/m1/s1
InChIKey BPRHUIZQVSMCRT-VEUZHWNKSA-N
Molar Mass 481.54 g/mol
Molecular Formula C22H28FN3O6S
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