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Semaxanib Properties

Semaxanib

Molecule Structure Image

Description

 

Semaxanib is a selective inhibitor of the tyrosine kinase activity of the vascular endothelial growth factor (VEGF) receptor Flk-1/KDR, is currently in Phase III clinical trials for the treatment of advanced malignancies. Semaxanib inhibits the VEGF-dependent mitogenic/proliferative response of human umbilical vein endothelial cells (HUVECs). In tumor xenograft models, SU5416 inhibits the growth of tumors from a variety of origins by inhibiting tumor angiogenesis.

Chemical Properties

CAS Number 204005-46-9
Chemical Composition (Z)-3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)indolin-2-one
Density 1.256 g/cm3
IUPAC Name (3Z)-3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one
InChI 1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8-
InChIKey WUWDLXZGHZSWQZ-WQLSENKSSA-N
Melting Point 220-222 ºC
Molar Mass 238.28 g/mol
Molecular Formula C15H14N2O
Synonyms SU5416;Sugen 5416;Semoxind;3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one;(3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-2-indolinone;(3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]indolin-2-one;(Z)-3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)indolin-2-one;1,3-Dihydro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-2H-indol-2-one;3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one