Stavudine Properties, Molecular Formula, Applications - WorldOfChemicals

Stavudine Properties

Stavudine

Stavudine Molecular Structure-Molecule Struture
Molecule Structure Image

Description

 

Stavudine is a dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.Stavudine inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA.Side effects include peripheral neuropathy tingling, burning, numbness, or pain in the hands or feet), fatal lactic acidosis has been reported in patients treated with stavudine (ZERIT) in combination with other antiretroviral agents, severe liver enlargement, inflammation (pain and swelling) of the liver, and liver failure.

Chemical Properties

Appearance Colourless Solid
Brand Name Zerit
Zerit XR
Zerut XR
CAS Number 3056-17-5
Density 1.374 g/cm3
IUPAC Name 4-Hydroxy-1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydro-2-furanyl]-5-methyl-2(1H)-pyrimidinone
InChI 1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2-4,7-8,13H,5H2,1H3,(H,11,14,15)/t7-,8+/m0/s1
InChIKey XNKLLVCARDGLGL-JGVFFNPUSA-N
Melting Point 159-160 °C
Molar Mass 224.21 g/mol
Molecular Formula C10H12N2O4
RTECS Number XP2075000
Solubility 5-10 g/100 ml
Synonyms 2',3'-Didehydro-3'-deoxythimidine;
3'-Deoxy-2'-thymidinene;
Estavudina [INN-Spanish];STV;
Stavudine [Usan:Ban:Inn];Stavudinum [INN-Latin];1-(2,3-Dideoxy-b-glycero-pent-2-enofuranosyl)thymine;1-((2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;1-(2,3-Dideoxy-β-D-glycero-pent-2-enofuranosyl)thymine;17-N,N-diethylcarbamoyl-4-methyl-4-azaandrostane-3-one
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