Tadalafil Properties, Molecular Formula, Applications - WorldOfChemicals

Tadalafil Properties


Tadalafil Molecular Structure-Molecule 3D Struture
Molecule 3D Structure Image
Tadalafil Structure-Molecule Struture
Molecule Structure Image



Tadalafil is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) for the treatment of pulmonary arterial hypertension. It initially was developed by the biotechnology company ICOS. The most common side effects when using tadalafil are headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. These side effects reflect the ability of PDE5 inhibition to vasodilate (cause blood vessels to widen) and usually go away after a few hours. Back pain and muscle aches can occur 12 to 24 hours after taking the drug, and the symptom usually disappears after 48 hours.

Chemical Properties

Appearance White to off-white crystalline solid
Brand Name Cialis;Adcirca;Tadacip
CAS Number 171596-29-5
Density 1.51 g/cm3
IUPAC Name (6R-trans)-6-(1,3-Benzodioxol-5-yl)- 2,3,6,7,12,12a-Hexahydro-2-Methyl-Pyrazino [1', 2':1,6] Pyrido[3,4-b]Indole-1,4-Dione
InChI 1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1
Melting Point 298-300°C
Molar Mass 389.41g/mol
Molecular Formula C22H19N3O4
Synonyms Tadalafil;Cialis;IC 351;(6r,12ar)-6-(1,3-Benzodioxol-5-Yl)-2,3,6,7,12,12a-Hexahydro-2-Methyl-Pyrazino[1',2':1,6]Pyrido[3,4-B]Indole-1,4-Dione