Tipranavir Properties, Molecular Formula, Applications - WorldOfChemicals

Tipranavir Properties

Tipranavir

Molecule Structure Image

Description

 

Tipranavir is a nonpeptidic protease inhibitor. It is administered with ritonavir in combination therapy to treat HIV infection. It has the ability to inhibit the replication of viruses that are resistant to other protease inhibitors and it recommended for patients who are resistant to other treatments. Resistance to tipranavir itself seems to require multiple mutations. Side effects of tipranavir can be more severe than other anti-retrovirals. Some side effects include intracranial hemorraging, hepatitis, and diabetes mellitus. The drug has also been shown to cause increases in total cholesterol and triglycerides.

Chemical Properties

Appearance White solid
Brand Name Aptivus
CAS Number 174484-41-4
Density 1.313 g/cm3
IUPAC Name N-{3-[(1R)-1-[(2R)-6-hydroxy-4-oxo-2-(2-phenylethyl)-2-propyl-3,4-dihydro-2H-pyran-5-yl]propyl]phenyl}-5-(trifluoromethyl)pyridine-2-sulfonamide
InChI 1S/C31H33F3N2O5S/c1-3-16-30(17-15-21-9-6-5-7-10-21)19-26(37)28(29(38)41-30)25(4-2)22-11-8-12-24(18-22)36-42(39,40)27-14-13-23(20-35-27)31(32,33)34/h5-14,18,20,25,36-37H,3-4,15-17,19H2,1-2H3/t25-,30-/m1/s1
InChIKey SUJUHGSWHZTSEU-FYBSXPHGSA-N
Melting Point 86-89 °C
Molar Mass 602.66 g/mol
Molecular Formula C31H33F3N2O5S