Trimethoprim Properties, Molecular Formula, Applications - WorldOfChemicals

Trimethoprim Properties

Trimethoprim

Molecule 3D Structure Image
Molecule Structure Image

Description

 

Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections. It belongs to the class of chemotherapeutic agents known as dihydrofolate reductase inhibitors. It is potentiated by sulfonamides and the trimethoprim-sulfamethoxazole combination is the form most often used. It is sometimes used alone as an antimalarial. Trimethoprim acts by interfering with the action of bacterial dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the intermediate Thymidine monophosphate (dTMP), precursor of DNA metabolite Thymidine triphosphate. Trimethoprim used as monotherapy, is indicated for the prophylaxis and treatment of urinary tract infections.

Chemical Properties

Boiling Point 526°C
Brand Name Abacin; Abaprim; Alprim; Apo-Sulfatrim; Bactin; Bactramin; Bactrim; Bactrim DS; Bactrim Pediatric; Baktar; Chemotrim; Co-Trimoxazole; Comox; Cotrim; Cotrim D.S.; Drylin; Eusaprim; Fectrim; Gantaprim; Gantrim; Idotrim; Imexim; Instalac; Ipral; Kepinol; Laratrim;Lidaprim; Linaris; Methoprim; Microtrim; Monoprim; Monotrim; Monotrimin; Nopil;Oraprim; Priloprim; Primosept; Primsol; Proloprim; Septra; Septra DS; Septra Grape; Septrin; Sigaprim; Sulfamethoprim; Sulfamethoprim-DS; Sulfatrim; Sulfatrim Pediatric; Sulfatrim-DS; Sulfatrim-SS; Sulfotrim; Sulmeprim; Sulprim; Sumetrolim; Supracombin; Suprim; Syraprim; Teleprim; Thiocuran; Tiempe; Tmp-Ratiopharm; Trigonyl; Trimanyl; Trimesulf; Trimeth/Sulfa; Trimethioprim; Trimethopriom; Trimetoprim; Trimexazole; Trimogal; Trimopan; Trimpex; Trimpex 200; Triprim; Unitrim; Uretrim; Uro-Septra; Uroplus; Uroplus DS; Uroplus SS; Wellcoprim
CAS Number 738-70-5
ChEBI 9731
Density 1.252 g/cm3
EINECS Number 212-006-2
InChI 1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
InChIKey IEDVJHCEMCRBQM-UHFFFAOYSA-N
Melting Point 199-203°C
Molar Mass 290.32 g/mol
Molecular Formula C14H18N4O3
RTECS Number UV8225000
Solubility 12.1 mg/ml