sarms powder steroids pirfenidone 53179-13-8 anti fibrosis Supplier - Guangzhou Kafen Biotech Co.,Ltd.
You Are In:Home/Chemical Categories/Sarms Powder Steroids Pirfenidone 53179-13-8 Anti Fibrosis Suppliers/sarms powder steroids pirfenidone 53179-13-8 anti fibrosis

sarms powder steroids pirfenidone 53179-13-8 anti fibrosis

Description :

Welcome to inquiry!

Email: tony@kafenbio.com

WhatsApp: +8618002259573

Skype: tony_14616

www.pharmhormone.com

 
Sarms Powder Steroids Pirfenidone 53179-13-8 Anti Fibrosis 
 
Pirfenidone Basic information
 
Product Name: Pirfenidone
Synonyms: 5-methyl-1-phenyl-2(1h)-pyridon;amr-69;PIRFENIDONE;5-METHYL-1-PHENYL-1H-PYRIDIN-2-ONE;5-METHYL-1-PHENYL-2(1H)-PYRIDINONE;5-METHYL-1-PHENYL-2-(1H)-PYRIDONE;5-Methyl-N-phenyl-2-1H-pyridone;Pirfenidone also see 5-Methyl-1-Phenyl-2(1H)-Pyridinone
CAS: 53179-13-8
MF: C12H11NO
MW: 185.22
EINECS: N/A
Melting point: 96-97°C
Storage temp.: Store at RT
Solubility: DMSO: ≥10 mg/mL, Soluble
Chemical Properties: Off-White Solid
Usage: Pirfenidone has demonstrated activity in multiple fibrotic conditions, including those of the lung, kidney and liver
Product Categories: Aromatics Compounds;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Cytokine signaling;Inhibitors.
 
Pirfenidone Description:
 
Pirfenidone (INN, BAN) is an anti-fibrotic drug for the treatment of idiopathic pulmonary fibrosis (IPF). It works by reducing lung fibrosis through downregulation of the production of growth factors and procollagens I and II.
 
It is a drug developed by several companies worldwide, including InterMune Inc. (now part of Roche), Shionogi Ltd., and GNI Group Ltd. In 2008, it was first approved in Japan for the treatment of IPF after clinical trials, under the trade name of Pirespa by Shionogi & Co. In October 2010, the Indian Company Cipla launched it as Pirfenex. In 2011, it was approved for use in Europe for IPF; it was approved in Canada in 2012 ; and was approved in the United States in October 2014 under the same name. In September 2011, the Chinese State Food and Drug Administration provided GNI Group Ltd with new drug approval of pirfenidone in China, and later manufacture approval in 2013 under the trade name of Etuary.
 
In 2014 it was approved in Mexico under the name KitosCell LP, indicated for pulmonary fibrosis and liver fibrosis.There is also a topical form created for the treatment of abnormal wound healing processes.
 
Pirfenidone Application:
 
In vitro, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation. Pirfenidone can inhibit the TGF - beta - 1 inducing fibroblast collagen formation. Inhibition of PDGF, FGF and TGF - beta - 1 inducing fibroblast proliferation. In hamster model, pirfenidone, taken by mouth, that can the prevention and treatment of pulmonary fibrosis . Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can also be keloid grafting for the treatment of nude mice. Pirfenidone 0.01 1 mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also. Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity.
 

Seller Info :

Guangzhou Kafen Biotech Co.,Ltd.

Product Details :

Brandkafen
Cas Number53179-13-8

Categories :

Human Hormones
About Suppliers :
Guangzhou Kafen Biotech Co.,Ltd.
Guangzhou Kafen Biotech Co.,Ltd is a high-tech and professional company founded in 2002,which specialized in developing, manufacturing,distributing steroid hormone powders and intermediates.We have been devoted in R&D, production and marketing steroid hormone and pharmaceutical raw materials. Wit Read More..

Buy sarms powder steroids pirfenidone 53179-13-8 anti fibrosis from other suppliers.View All


www.worldofchemicals.com uses cookies to ensure that we give you the best experience on our website. By using this site, you agree to our Privacy Policy and our Terms of Use. X